Records of Natural Products

Records of Natural Products

Evaluation of Anti-inflammatory and Immunosuppressive Properties of Cynanchum ascyrifolium Matsum. and its Active Secondary Metabolites

Yazarlar: Chao-Feng Zhang, Xiu-Fen Liu, Yan-Yan Zhao Mian Zhang

Cilt 10 , Sayı 4 , 2016 , Sayfalar 526 - 529

Konular:-

Anahtar Kelimeler:Cynanchum ascyrifolium Matsum.,Anti-inflammation,Immunosuppression,Cynanoside A

Özet: The ethanol extract of Cynanchum ascyrifolium Matsum. showed significant anti-inflammatory and immunosuppressive activities with dose dependent manner using in vitro experiments. Then, the bioassay-guided ethanol extract lead to identification of four active compounds, namely ursolic acid (1), maslinic acid (2), cynanoside A (3) and syringaresinol (4). Among these compounds, cynanoside A (3), a C21 steroid, exhibited the highest anti-inflammatory and immunosuppressive effect on the Con-A or LPS activated lymphocytes at the concentration of 1 m M (P<0.01 vs model group). The results provided experimental evidence for the traditional use of C. ascyrifolium Matsum. in treating various disease associated with inflammation.

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@article{2016, title={Evaluation of Anti-inflammatory and Immunosuppressive Properties of Cynanchum ascyrifolium Matsum. and its Active Secondary Metabolites}, volume={10}, number={526–529}, publisher={Records of Natural Products}, author={Chao-Feng Zhang, Xiu-Fen Liu, Yan-Yan Zhao  Mian Zhang}, year={2016} }
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Chao-Feng Zhang, Xiu-Fen Liu, Yan-Yan Zhao  Mian Zhang. (2016). Evaluation of Anti-inflammatory and Immunosuppressive Properties of Cynanchum ascyrifolium Matsum. and its Active Secondary Metabolites (Vol. 10). Vol. 10. Records of Natural Products.
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Chao-Feng Zhang, Xiu-Fen Liu, Yan-Yan Zhao  Mian Zhang. Evaluation of Anti-Inflammatory and Immunosuppressive Properties of Cynanchum Ascyrifolium Matsum. and Its Active Secondary Metabolites. no. 526–529, Records of Natural Products, 2016.
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