Records of Natural Products

Records of Natural Products

The First Solid-phase Synthesis and Structural Studies on Phakellistatin 15

Yazarlar: Farzana Shaheen, Muhammad Asad Ziaee, Syed Abid Ali, Shabana U. Simjee, Aqeel Ahmed M. Iqbal Choudhary

Cilt 10 , Sayı 4 , 2016 , Sayfalar 397 - 406

Konular:-

Anahtar Kelimeler:Cyclic peptide,Phakellistatin,Solid-phase synthesis,Safety-catch linker

Özet:  Phakellistatin 15 (1) is a cyclic octapeptide, containing three proline moieties, all in the trans form. It is a constituent of South China Sea sponge Phakella fusca and reported to have antitumor activity. This study describes the first solid-phase total synthesis of peptide 1 by using Kenner's N-acyl sulfonamide "safety-catch" linker. The structural analysis of peptide 1 was performed by mass, NMR and CD studies. The spectral data of synthetic peptide 1 was found to be identical to that reported for natural peptide. However, the synthetic peptide was found to be inactive on human glioblastoma (U-87), pancreatic cancer (PSN-1) and human non-small cell lung cancer (NCI-H460) cells.

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@article{2016, title={The First Solid-phase Synthesis and Structural Studies on Phakellistatin 15}, volume={10}, number={397–406}, publisher={Records of Natural Products}, author={Farzana Shaheen, Muhammad Asad Ziaee, Syed Abid Ali, Shabana U. Simjee, Aqeel Ahmed  M. Iqbal Choudhary}, year={2016} }
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Farzana Shaheen, Muhammad Asad Ziaee, Syed Abid Ali, Shabana U. Simjee, Aqeel Ahmed  M. Iqbal Choudhary. (2016). The First Solid-phase Synthesis and Structural Studies on Phakellistatin 15 (Vol. 10). Vol. 10. Records of Natural Products.
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Farzana Shaheen, Muhammad Asad Ziaee, Syed Abid Ali, Shabana U. Simjee, Aqeel Ahmed  M. Iqbal Choudhary. The First Solid-Phase Synthesis and Structural Studies on Phakellistatin 15. no. 397–406, Records of Natural Products, 2016.
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