Records of Natural Products

Records of Natural Products

Calotroposide S, New Oxypregnane Oligoglycoside from Calotropis procera Root Bark

Yazarlar: Sabrin R. M. Ibrahim, Gamal A. Mohamed, Lamiaa A. Shaala Diaa T. A. Youssef

Cilt 10 , Sayı 6 , 2016 , Sayfalar 761 - 765

Konular:-

Anahtar Kelimeler:Calotropis procera,Asclepiadaceae,Calotroposide S,Anti-proliferative activity

Özet: Calotroposide S (1), a new oxypregnane oligoglycoside has been isolated from the n-butanol fraction of Calotropis procera (Ait) R. Br. root bark. The structure of 1 was assigned based on various spectroscopic analyses. Calotroposide S (1) possesses the 12-O-benzoylisolineolon aglycone moiety with eight sugar residues attached to C-3 of the aglycone. It showed potent anti-proliferative activity towards PC-3 prostate cancer, A549 non-small cell lung cancer (NSCLC), and U373 glioblastoma (GBM) cell lines with IC 50 0.18, 0.2, and 0.06 µM, respectively compared with cisplatin and carboplatin.

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@article{2016, title={Calotroposide S, New Oxypregnane Oligoglycoside from Calotropis procera Root Bark}, volume={10}, number={761–765}, publisher={Records of Natural Products}, author={Sabrin R. M. Ibrahim, Gamal A. Mohamed, Lamiaa A. Shaala  Diaa T. A. Youssef}, year={2016} }
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Sabrin R. M. Ibrahim, Gamal A. Mohamed, Lamiaa A. Shaala  Diaa T. A. Youssef. (2016). Calotroposide S, New Oxypregnane Oligoglycoside from Calotropis procera Root Bark (Vol. 10). Vol. 10. Records of Natural Products.
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Sabrin R. M. Ibrahim, Gamal A. Mohamed, Lamiaa A. Shaala  Diaa T. A. Youssef. Calotroposide S, New Oxypregnane Oligoglycoside from Calotropis Procera Root Bark. no. 761–765, Records of Natural Products, 2016.
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