Records of Natural Products

Records of Natural Products

A New Acetylenic Compound and Other Bioactive Metabolites from a Shark Gill-derived Penicillium Strain

Yazarlar: Yi Zhang, Yan Feng, Markus Kramer, Frank Essmann Stephanie Grond

Cilt 11 , Sayı 1 , 2017 , Sayfalar 31 - 36

Konular:-

Anahtar Kelimeler:Econdary metabolites ,Shark,Penicillium polonicum ,Bioactivity

Özet: Nine chiral compounds (1−9) were isolated from the static fermentation culture of a shark gill-derived fungus Penicillium polonicum AP2T1. These compounds include a new acetylenic aromatic ether (1 , (-)-WA ), four alkaloids ( a urantiomide C ( 2 ), fructigenine A (3), cyclopenin (4) and cyclopenol (5)) and four oxygenated compounds ((R)-penipratynolene (6), (3S,4S)-3,4-dihydro-3,4,8-trihydroxyl-naphthalenone (7), verrucosidin (8) and norverrucosidin (9)). Their structures were elucidated by MS, NMR , optical rotation and circular dichroism (CD) . In antimicrobial tests , compounds 1–4, 6 and 8–9 showed weak antibacterial activity against Staphylococcus aureus, Bacillus subtilis, and/or Escherichia coli.Compounds 3, 8 and 9 also exhibited moderate toxicity against Artemia salina larva , and showed cytotoxicity against human colon cancer cell line HCT116.

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@article{2017, title={A New Acetylenic Compound and Other Bioactive Metabolites from a Shark Gill-derived Penicillium Strain}, volume={11}, number={31–36}, publisher={Records of Natural Products}, author={Yi Zhang, Yan Feng, Markus Kramer, Frank Essmann  Stephanie Grond}, year={2017} }
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Yi Zhang, Yan Feng, Markus Kramer, Frank Essmann  Stephanie Grond. (2017). A New Acetylenic Compound and Other Bioactive Metabolites from a Shark Gill-derived Penicillium Strain (Vol. 11). Vol. 11. Records of Natural Products.
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Yi Zhang, Yan Feng, Markus Kramer, Frank Essmann  Stephanie Grond. A New Acetylenic Compound and Other Bioactive Metabolites from a Shark Gill-Derived Penicillium Strain. no. 31–36, Records of Natural Products, 2017.
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