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Records of Natural Products
Yazarlar: Ya-Shuo Ren, Zheng Li, Feng-Qing Xu, Li-li Li, De-Ling Wu, Wei Zhang Chuan-shan Jin
Konular:-
Anahtar Kelimeler:Buddleja lindleyana ,Oleanolic triterpene ,Neurotoxicity effect
Özet: In the phytochemical investigation of Buddleja lindleyana , a new 3-acetyl substituted triterpene, 13, 28-epoxy-23-hydroxy-3β-acetoxy-olean-11-ene (1), together with four same skeleton type known compounds (2-5) were isolated. The structure of 1 was elucidated by means of extensive spectroscopic analysis. Their neuroprotective effect against 1-methyl-4 -phenylpyridinium ion-induced (MPP +-induced) neurotoxicity in SH-SY5Y cells were evaluated. The structure activity relationship of compounds 1-5 has been discussed preliminarily.