Records of Natural Products

Yazarlar: Tunay Karan, Ilyas Yildiz, Ali Aydin Ramazan Erenler

Konular:-

Anahtar Kelimeler:Inula graveolens ,Essential oil,Antitumor activity

Özet: Inula species are medicinal and aromatic plants used for folk medicine extensively. In this work, hydrodistilled essential oil of Inula graveolens (Linnaeus) Desf. analyzed by GC-MS which revealed that bornyl acetate was the major product (69.15%). Camphene was the second major compound (11.11%). Antiproliferative activity of the essential oil and bornyl acetate was investigated on HeLa (human cervix carcinoma), HT29 (human colon carcinoma) , A549 (human lung carcinoma), MCF7 ( human breast adenocarcinoma) cancer cells and FL (human amnion cells) normal cells. The cytotoxicity was executed by a Lactate Dehydrogenase (LDH) Cytotoxicity Detection Kit. Essential oil and bornyl acetate displayed the outstanding activities on HeLa (IC 50, 64.1, 72.0 µg/mL), HT29 (IC 50, 24.6, 60.5 µg/mL), A549 (IC 50, 28.3, 44.1 µg/mL), MCF-7 (IC 50, 66.5, 85.6 µg/mL), and FL (IC 50, 42.1, 50.6 µg/mL) cell lines respectively.

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