Records of Natural Products

Records of Natural Products

Evaluation of Cytotoxic Activity in vitro of Charantin A Extracted from Momordica charantia

Yazarlar: Zijun Guo, Guocai Wang, Maoxin Zhang, Guangwen Liang, Qiang Li Bing Ling

Cilt 12 , Sayı 5 , 2018 , Sayfalar 416 - 425

Konular:-

Anahtar Kelimeler:Momordica charantia,Tetracyclic triterpene,Cytotoxicity,Cell cycle,Calcium homeostasis,Spodoptera litura

Özet: Charantins A is cucurbitane-type triterpene glycoside secondary metabolites derived from Momordica charantia . Here, biological activities of charantin A and mode of action to Spodoptera litura ovary cell line ( SpLi-221) were evaluated. We investigated the effects of charantins A on cell growth inhibition compared with charantins B, momordicin I and azadirachtin A. Among them, charantins A showed the most potent activity against SpLi-221 cells with the lowest IC 50 values, and in a time- and dose-dependent manner. Moreover, the cell morphology changed after charantin A treatment, including cytoplasm leakage, irregular morphology, and apoptotic bodies. In addition, the flow cytometry assay confirmed that charantin A promoted the occurrence of cells’ G2/M block and apoptosis, as evidenced by an increased ratio of cells in the sub-G1 phase. Furthermore, cell membrane disruption and increase of intracellular calcium levels were observed following charantin A treatment. These findings provide new clues regarding the role of cucurbitane-type triterpene glycosides as potential novel pesticides for pest control.

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@article{2018, title={Evaluation of Cytotoxic Activity in vitro of Charantin A Extracted from Momordica charantia}, volume={12}, number={416–425}, publisher={Records of Natural Products}, author={Zijun Guo, Guocai Wang, Maoxin Zhang, Guangwen Liang, Qiang Li  Bing Ling}, year={2018} }
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Zijun Guo, Guocai Wang, Maoxin Zhang, Guangwen Liang, Qiang Li  Bing Ling. (2018). Evaluation of Cytotoxic Activity in vitro of Charantin A Extracted from Momordica charantia (Vol. 12). Vol. 12. Records of Natural Products.
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Zijun Guo, Guocai Wang, Maoxin Zhang, Guangwen Liang, Qiang Li  Bing Ling. Evaluation of Cytotoxic Activity in Vitro of Charantin A Extracted from Momordica Charantia. no. 416–425, Records of Natural Products, 2018.
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