Records of Natural Products

Records of Natural Products

Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp.

Yazarlar: Chin-Soon Phan, Takashi Kamada, Toshiyuki Hamada Charles S. Vairappan

Cilt 12 , Sayı 6 , 2018 , Sayfalar 643 - 647

Konular:-

Anahtar Kelimeler:Borneo,Sponge,Sesterterpenes,Adult T-cell leukemia,S1T

Özet: Four scalarane sesterterpenoids, scalarolide acetate (1), scalarolide (2), 12-O-deacetyl-12-epi-19-O-methylscalarin (3) and methyl 18-hydroxy-19-norscalar-16-en-20-carboxylate (4) were isolated from the Bornean sponge Spongia sp. The distinction between 12 a -OAc and 12 b -OAc, and 19-olide and 20-olide in sesterterpenes were revealed as well as previously not assigned relative configuration at 18-OH of 4 is reported herein for the first time. In addition, compounds 1-3 showed strong cytotoxic activities against adult T-cell leukemia (ATL), S1T cells. This is the first record of scalarane sesterterpenes from the Bornean sponge.

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@article{2018, title={Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp.}, volume={12}, number={643–647}, publisher={Records of Natural Products}, author={Chin-Soon Phan, Takashi Kamada, Toshiyuki Hamada  Charles S. Vairappan}, year={2018} }
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Chin-Soon Phan, Takashi Kamada, Toshiyuki Hamada  Charles S. Vairappan. (2018). Cytotoxic Sesterterpenoids from Bornean Sponge Spongia sp. (Vol. 12). Vol. 12. Records of Natural Products.
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Chin-Soon Phan, Takashi Kamada, Toshiyuki Hamada  Charles S. Vairappan. Cytotoxic Sesterterpenoids from Bornean Sponge Spongia Sp. no. 643–647, Records of Natural Products, 2018.
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