Records of Natural Products

Records of Natural Products

Diterpenoid Alkaloids from the Roots of Aconitum sinomontanum and Their Evaluation of Immunotoxicity

Yazarlar: Jiao Zhang, Yuze Li, Yuwen Cui, Pu Jia, Zhenggang Yue, Bei Song Xiaomei Song

Cilt 13 , Sayı 2 , 2019 , Sayfalar 114 - 120

Konular:-

Anahtar Kelimeler:Aconitum sinomontanum Nakai,Diterpenoid alkaloids,Immunotoxicity

Özet:  One new C18-diterpenoid alkaloid, along with four known diterpenoid alkaloids have been isolated from the roots of Aconitum sinomontanum.  Their structures were established as sinomontanine I (1), delcosine (2), lepenine (3), napelline (4), and kirinine B (5) by extensive spectroscopic techniques and chemical methods.The immunosuppressive effects of compounds 1–4 were evaluated in vitro through ConA-induced or LPS-induced splenocyte proliferation, with IC50 values of 8.909 μM, 1.515 μM，5.078 μM, and 1.167 μM (ConA-induced)，or 3.661 μM, 4.417 μM, 5.129 μM, and 1.830 μM (LPS-induced), and compounds 1–4 showed a significant cytotoxic effect with CC50 values of 447.5 μM, 702.2 μM, 310.6 μM and 794.1 μM, respectively. The CC50/IC50 value of 2 and 3 suggested that these compounds were potential immunosuppressive agents for the treatment of autoimmune diseases characterized by arthritis, such as rheumatoid arthritis..

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@article{2019, title={Diterpenoid Alkaloids from the Roots of Aconitum sinomontanum and Their Evaluation of Immunotoxicity}, volume={13}, number={114–120}, publisher={Records of Natural Products}, author={Jiao Zhang, Yuze Li, Yuwen Cui, Pu Jia, Zhenggang Yue, Bei Song  Xiaomei Song}, year={2019} }
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Jiao Zhang, Yuze Li, Yuwen Cui, Pu Jia, Zhenggang Yue, Bei Song  Xiaomei Song. (2019). Diterpenoid Alkaloids from the Roots of Aconitum sinomontanum and Their Evaluation of Immunotoxicity (Vol. 13). Vol. 13. Records of Natural Products.
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Jiao Zhang, Yuze Li, Yuwen Cui, Pu Jia, Zhenggang Yue, Bei Song  Xiaomei Song. Diterpenoid Alkaloids from the Roots of Aconitum Sinomontanum and Their Evaluation of Immunotoxicity. no. 114–120, Records of Natural Products, 2019.
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