Records of Natural Products

Records of Natural Products

Histone Deacetylase Inhibitor Induced Lipase Inhibitors from Endophytic Phomopsis sp. 0391

Yazarlar: Shan-ling Sheng , Yan-ping Li , Hai-ying Xiang , Yun Liu , Yudan Wang , Ling-peng Kong , Gang Du , Qiufen Hu , Yi-jian Chen Weiguang Wang

Cilt 14 , Sayı - , 2020 , Sayfalar 42 - 47

Konular:-

Anahtar Kelimeler:Natural products ,Endophytic fungi ,Chemical epigenetics approach ,Lipase inhibitor

Özet: Abstract: Seven compounds including a new one named as 13-angeloyloxy-diplosporin (1) were isolated from the endophytic Phomopsis sp. 0391 cultivated in the presence of a histone deacetylase inhibitor. All of these isolates were evaluated for lipase suppressive activities and we firstly found that compounds cytosporone B (5) and dothiorelone A (6) displayed significant lipase inhibited activities compared to the positive control (Orlistat, IC50 = 43 μg/mL) with the IC50 values at 115 and 275 μg/mL, respectively.

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@article{2020, title={Histone Deacetylase Inhibitor Induced Lipase Inhibitors from Endophytic Phomopsis sp. 0391}, volume={14}, number={42–47}, publisher={Records of Natural Products}, author={Shan-ling Sheng , Yan-ping Li , Hai-ying Xiang , Yun Liu , Yudan Wang , Ling-peng Kong , Gang Du , Qiufen Hu , Yi-jian Chen  Weiguang Wang}, year={2020} }
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Shan-ling Sheng , Yan-ping Li , Hai-ying Xiang , Yun Liu , Yudan Wang , Ling-peng Kong , Gang Du , Qiufen Hu , Yi-jian Chen  Weiguang Wang. (2020). Histone Deacetylase Inhibitor Induced Lipase Inhibitors from Endophytic Phomopsis sp. 0391 (Vol. 14). Vol. 14. Records of Natural Products.
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Shan-ling Sheng , Yan-ping Li , Hai-ying Xiang , Yun Liu , Yudan Wang , Ling-peng Kong , Gang Du , Qiufen Hu , Yi-jian Chen  Weiguang Wang. Histone Deacetylase Inhibitor Induced Lipase Inhibitors from Endophytic Phomopsis Sp. 0391. no. 42–47, Records of Natural Products, 2020.
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