Records of Natural Products

Records of Natural Products

A New 2,2′-dipyridine and Its Analogues from Endophytic Streptomyces sp. KIB H017c with Potent Cytotoxicity

Yazarlar: Xiao-yan Ma , Feng-xian Yang , Can Su , Yijun Yan Sheng-Xiong Huang

Cilt 14 , Sayı 2 , 2020 , Sayfalar 98 - 104

Konular:-

Anahtar Kelimeler:Endophytic Streptomyces ,2,′-dipyridine ,Antimicrobial activity ,Cytotoxicity

Özet: A new 2,2′-dipyridyl compound 1, along with three known analogues (2–4), was isolated from the culture broth of endophytic Streptomyces sp. KIB H017c derived from Fragaria ananassa. Their structures were elucidated by analysis of 1D and 2D NMR as well as HRESIMS data, and comparison with literature data. The biological properties of all isolates were explored for antibacterial, antifungal and cytotoxic activity. All four compounds exhibited weak antifungal activity against Saccharomyces cerevisiae, and compound 4 exhibited weak antifungal activity against Penicillium decumbens ATCC 10436. Compound 3 displayed moderate cytotoxic activity against HL-60 (human myeloid leukemia), SMMC-7721 (hepatocellular carcinoma), A-549 (lung carcinoma), MCF-7 (breast adenocarcinoma), and SW480 (colon carcinoma) with IC50 values of 12.10, 11.15, 23.64, 31.13 and 14.62 μM, respectively. Compound 4 exhibited potent activity against A-549 (lung carcinoma), MCF-7 (breast adenocarcinoma), and SW480 (colon carcinoma) with IC50 values 0.88, 0.34 and 0.55 μM, respectively.

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@article{2020, title={A New 2,2′-dipyridine and Its Analogues from Endophytic Streptomyces sp. KIB H017c with Potent Cytotoxicity}, volume={14}, number={98–104}, publisher={Records of Natural Products}, author={Xiao-yan Ma , Feng-xian Yang , Can Su , Yijun Yan  Sheng-Xiong Huang}, year={2020} }
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Xiao-yan Ma , Feng-xian Yang , Can Su , Yijun Yan  Sheng-Xiong Huang. (2020). A New 2,2′-dipyridine and Its Analogues from Endophytic Streptomyces sp. KIB H017c with Potent Cytotoxicity (Vol. 14). Vol. 14. Records of Natural Products.
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Xiao-yan Ma , Feng-xian Yang , Can Su , Yijun Yan  Sheng-Xiong Huang. A New 2,2′-Dipyridine and Its Analogues from Endophytic Streptomyces Sp. KIB H017c with Potent Cytotoxicity. no. 98–104, Records of Natural Products, 2020.
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