Records of Natural Products

Records of Natural Products

A New Sesquiterpene and Known Alkaloids from Toddalia asiatica and Their Inhibitions Against Phosphodiesterase-4

Yazarlar: Tingting Lin Gang Chen

Cilt 14 , Sayı 3 , 2020 , Sayfalar 207 - 212

Konular:-

Anahtar Kelimeler:Toddalia asiatica ,Sesquiterpene ,Alkaloids ,Phosphodiesterase-4

Özet: A new sesquiterpene (1) and nine known alkaloids (2-10) were isolated from the roots of Toddalia asiatica. The structure of compound 1 were resolved by NMR and HRESI data, as well as ECD calculation for determining the absolute configuration. The known compounds were identified to be 8-acetonyldihydronitidine (2), 8-acetonyldihydroavicine (3), dihydronitidine (4), oxynitidine (5), decarine (6), skimmianine (7), g-fagarine (8), N-methylflindersine (9), and 4-methoxy-N-methyl-2-quinolone (10) by comparing the NMR data with those in the literature. Compound 1 is the first eremophilane-type sesquiterpenoid isolated from this species. The known compounds 2, 3, and 6 were discovered for the first time from the genus Toddalia. All the isolated compounds were evaluated for their inhibitory effects against phosphodiesterase-4, as result, compound 2 showed strong inhibitory effect against phosphodiesterase-4 with an IC50 value of 5.14 mM.

ATIFLAR
Atıf Yapan Eserler
Henüz Atıf Yapılmamıştır
KAYNAK GÖSTER
BibTex
KOPYALA
@article{2020, title={A New Sesquiterpene and Known Alkaloids from Toddalia asiatica and Their Inhibitions Against Phosphodiesterase-4}, volume={14}, number={207–212}, publisher={Records of Natural Products}, author={Tingting Lin  Gang Chen}, year={2020} }
APA
KOPYALA
Tingting Lin  Gang Chen. (2020). A New Sesquiterpene and Known Alkaloids from Toddalia asiatica and Their Inhibitions Against Phosphodiesterase-4 (Vol. 14). Vol. 14. Records of Natural Products.
MLA
KOPYALA
Tingting Lin  Gang Chen. A New Sesquiterpene and Known Alkaloids from Toddalia Asiatica and Their Inhibitions Against Phosphodiesterase-4. no. 207–212, Records of Natural Products, 2020.
Atıf Görüntüle
PDF Görüntüle
Kaynak Görüntüle
Paylaş
Dergi Bilgileri